Mostly Mac uses and recommends Xero as a great replacement for the likes of MYOB. Having slugged through MYOB AccountEdge for the first 2 years of my business, discovering Xero has been a dream come true.
Previously doing my books was a major chore and took up too much valuable time. Xero simplifies it all and almost makes it fun (almost!).
Also, Xero integrates beautifully with Vend and a growing list of add-on products.